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Literature summary extracted from

  • Boath, A.; Graf, C.; Lidome, E.; Ullrich, T.; Nussbaumer, P.; Bornancin, F.
    Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: comparative analysis to glucosylceramide and sphingomyelin (2008), J. Biol. Chem., 283, 8517-8526.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.138 Golgi apparatus ceramide is transported to the Golgi complex for phosphorylation by ceramide kinase Mus musculus 5794
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Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.138 Ca2+ the intracellular calcium chelator BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid) decreases ceramide 1-phosphate formation by almost 100%, demonstrating the total dependence of ceramide kinase on Ca2+-ions Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ceramide + ATP Mus musculus ceramide 1-phosphate is a sphingolipid that participates in cell signaling, but ceramide kinase is not the only source of ceramide 1-phosphate ceramide 1-phosphate + ADP
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Mus musculus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.138 femur extraction of bone marrow and preparation of macrophages Mus musculus
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2.7.1.138 macrophage bone marrow-derived macrophage, BMDM Mus musculus
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2.7.1.138 primary cell bone marrow-derived macrophage, BMDM Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 ceramide + ATP
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 Mus musculus ceramide 1-phosphate + ADP
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 ?
2.7.1.138 ceramide + ATP ceramide 1-phosphate is a sphingolipid that participates in cell signaling, but ceramide kinase is not the only source of ceramide 1-phosphate Mus musculus ceramide 1-phosphate + ADP
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 ?
2.7.1.138 N-((4-(4,4-difluoro-5-(2-thienyl)-4-bora-3alpha,4alpha-diaza-s-indacene-3-yl)phenoxy)acetyl)sphingosine + ATP TRB-ceramide Mus musculus N-((4-(4,4-difluoro-5- (2-thienyl)-4- bora-3a,4a-diaza-s-indacene-3-yl)phenoxy)acetyl)sphingosine 1-phosphate + ADP
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 ?
2.7.1.138 N-(5-(5,7-dimethyl-BODIPY)-L-pentanoyl)-D-erythrosphingosine + ATP DMB-C5 ceramide Mus musculus N-(5-(5,7-dimethyl-BODIPY)-L-pentanoyl)-D-erythrosphingosine 1-phosphate + ADP
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 ?
2.7.1.138 N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl-D-erythrosphingosine + ATP NBD-Cer, NBD-C6 ceramide Mus musculus N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl-D-erythrosphingosine 1-phosphate + ADP
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 CERK
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 Mus musculus